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Indeed, there is evidence to suggest that two distinct pools of S-nitrosylated proteins exist, one that is GSH stable and another that is GSH labile and subject to rapid conversion to a S-glutathionylated product

By breaking down intracellular components, autophagy sustains bioenergetic balance and promotes cell survival until favorable conditions are restored ( Autophagy is a highly conserved catabolic process involving four key steps: initiation, autophagosome formation and maturation, fusion with lysosomes, and degradation of autophagic cargo

Randomised clinical trials have demonstrated very low rates of hypoglycaemia with GLP-1 RAs when used as a monotherapy or in a combination therapy with other glucose-lowering drugs [16, 18, 20, 22, 24, 26, 28]

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