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25 The inhibition of these two proteins leads to a reduction in cholesterol levels, potentially benefiting the treatment of atherosclerotic conditions

This dual-pathway independence allows the compound to act synergistically with GHRH analogues in experimental models

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(Exenatide is FDA approved as monotherapy for the management of T2DM.) Explicitly stated in the guideline for patients requiring dual or triple therapy, the AACE/ACE preferentially recommends the addition of a GLP-1 receptor agonist or a DPP-4 inhibitor (sitagliptin, saxagliptin), citing their efficacy and safety profiles as preferred agents over TZDs or sulfonylureas (SUs)