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Following this, the receptors were then embedded in a rectangular 126 x 126 1-palmitoyl-2-oleyl-sn-glycerol-3-phosphocholine (POPC) bilayer (previously built by using the VMD Membrane Builder plugin 1.1 at considering the coordinates retrieved from the OPM database to gain the correct orientation within the membrane, while removing the lipid molecules overlapping the receptor TMD bundle

Of these, 173 patients initiated therapy while 42, who were prescribed but did not take the medication, served as controls

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