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For example, empagliflozin treatment uniquely improved cardiovascular disease risk profiles, increased microbiota richness and SCFA-producing taxa, and shifted circulating metabolites toward a more favorable cardiometabolic profile compared to metformin in a randomized clinical trial of 76 treatment-nave adults with T2DM and at least one cardiovascular disease risk factor [38]

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They are structurally unrelated peptides studied through different mechanisms