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The prescriber submits the PA through CVS Caremark's portal

Access to licensed clinicians who can screen you for contraindications and manage your side effects

dose escalation may take up to 8 weeks: Week 1: Inject 0.6 mg subcutaneously once a day Week 2: Inject 1.2 mg subcutaneously once a day Week 3: Inject 1.8 mg subcutaneously once a day Week 4: Inject 2.4 mg subcutaneously once a day Week 5: Inject 3 mg subcutaneously once a day Maintenance dose : 2.4 or 3 mg subcutaneously once a day If maintenance dose is not tolerated, discontinuation is recommended

Forced overexpression of survivin in glioblastoma cells prevented PT-141-induced cell death, establishing that survivin suppression is the primary mechanism underlying the peptide's anticancer activity