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Mutations in these genes not only cause severe obesity but also frequently lead to a broad spectrum of neurological phenotypes, including intellectual disability, developmental delay, and behavioral abnormalities (e.g., autism-like features), highlighting the foundational role of hypothalamic development in energy homeostasis [12,14]

Supply Chain and Go-to-Market Trends Supply chain strategies are evolving to support rapid category growth: Expansion of co-manufacturing and formulation capabilities Partnerships with ingredient suppliers for protein and fiber systems Investment in cold-chain and convenience food logistics Growth of digital and direct-to-consumer distribution models These strategies enable scalability while maintaining product consistency and innovation speed

Case presentation We report an 80-year-old male who presented with upper back pain for 3 months