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In controlled experimental settings, it is examined as a multi-receptor interacting peptide within defined receptor pathway models

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Methods We searched PubMed, Embase, Cochrane and ClinicalTrials.gov up until 27 October 2021 for randomised controlled trials with a duration of at least 12 weeks that compared once-weekly tirzepatide 5, 10 or 15 mg with placebo or other glucose-lowering drugs in adults with type 2 diabetes irrespective of their background glucose-lowering treatment

Both diet and lifestyle changes play crucial roles, alongside integrative treatments, in improving patient outcomes