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Sources Wilding JPH, Batterham RL, Calanna S, et al

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Known Vision-Related Risks Associated with GLP-1 Drugs Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) One of the most serious vision-related side effects linked to Ozempic, Wegovy, and similar GLP-1 drugs is NAION, a condition sometimes referred to as an eye stroke. NAION occurs when there is a sudden decrease or blockage of blood flow to the optic nerve, resulting in damage that prevents visual signals from reaching the brain

By secreting Il-1, TNF and complement component subunit 1q, the activated microglia induce the formation of neurotoxic reactive astrocytes which lose the ability to support neuronal survival, outgrowth, synaptogenesis and phagocytosis, leading to the death of neurons and oligodendrocytes (Zhang L