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Key points: In the only head-to-head trial, Wegovy produced 15.8% weight loss compared with 6.4% for Saxenda over the same 68-week period Wegovy 7.2 mg (approved January 2026) produces even greater results at 20.7% average weight loss Real-world data from Second Nature shows 19.1% weight loss with semaglutide when combined with behavioural support Semaglutide participants were nearly three times more likely to achieve at least 10% weight loss than liraglutide participants Side effects and tolerability Both medications share a similar side-effect profile, predominantly affecting the gastrointestinal tract

In these subjects, r-methuLeptin reduced food intake via neural circuits that reduce the cognition of food reward and enhance the response to satiety signals (Farooqi et al., 2012)

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