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Kessler said

Three studies contained data for more than one brain region: the results for these different brain regions were included in the final meta-analysis, giving a total of 11 studies in the final list of brain regions with data available

"We found that semaglutide was effective in improving time spent in the target blood sugar range and reduction in body weight compared to placebo group," said Viral Shah, MD, lead study author and IU School of Medicine professor of medicine

A useful comparison point is the acylation chemistry described for semaglutide by Lau and colleagues in the Journal of Medicinal Chemistry in 2015 [2], which introduced a C18 diacid linked through a spacer to achieve albumin binding on a GLP-1 scaffold