how glp 1 work for weight loss GLP-1 Agonists Obesity In Non-Diabetic Patients: Game Changer Or Overhyped? A Critical Analysis GlobalRPH GLP-1: Genetic Variants Related to

Dose reduction or discontinuation may be necessary if you develop: Persistent, intolerable gastrointestinal symptoms despite supportive measures Acute pancreatitis (discontinue permanently) Severe hypoglycemia, particularly if taking concurrent insulin or sulfonylureas Acute kidney injury or worsening renal function Gallbladder disease symptoms (abdominal pain, jaundice) Diabetic retinopathy complications (particularly with semaglutide) Severe hypersensitivity reactions including anaphylaxis or angioedema Pregnancy or plans for pregnancy (for semaglutide, discontinue at least two months before planned conception

doi: 10.1093/ije/dyw213 34 SchmidtMSchmidtSASandegaardJLEhrensteinVPedersenLSorensenHT

GLP-1 exerts its anorectic effect in part by acting on the hunger-satiety centre located in the arcuate nucleus of the hypothalamus, and in part by delaying gastric emptying

PMID: 31143899