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Which treatments are available

Direct nutrient stimulation may induce the initial release of GLP-1 from small intestinal EECs, while large intestinal EECs likely release GLP-1 via a neural hormonal reflex or from microbe-derived metabolites, although this remains to be explored 93,99 (see the Gut microbiotabrain connection section)

A recent study reported GLP-1 receptors on activated pancreatic stellate cells both in pancreatitis and isolated stellate cells in culture (81)

The three receptors to which retatrutide binds function as follows: GLP-1: Enhances satiety, reduces appetite, and promotes insulin secretion, directly supporting weight loss and blood glucose regulation