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Studies show that discontinuing GLP-1 therapy after achieving weight loss often results in weight regain, making long-term consistent dosing essential for sustained results
Needed a reset, met with Luke and very happy to revisit in person today
Semaglutide offers proven safety, pharmaceutical access, cardiovascular data, and good tolerability with meaningful weight loss
Retatrutide metabolic benefits Retatrutide produces all of the metabolic benefits seen with Mounjaro plus additional improvements that appear unique to triple agonism: Blood sugar control: HbA1c reductions of 1.3% to 2.0% at doses of 4-12 mg in type 2 diabetes Blood pressure: Systolic blood pressure reduction of up to 14.0 mmHg at the highest dose (roughly double what Mounjaro achieves) Lipids: Non-HDL cholesterol and triglyceride reductions Prediabetes reversal: 72% of participants with prediabetes at baseline reverted to normoglycemia Inflammatory markers: Significant reductions in high-sensitivity C-reactive protein But the standout metabolic benefit, the one that has researchers most excited, is the effect on liver health
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