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Murray PJ, Allen JE, Biswas SK, Fisher EA, Gilroy DW, Goerdt S, et al
Preclinical data have not shown prominent adverse effects, but human safety data are limited
In the LEADER (liraglutide) and SUSTAIN-6 (semaglutide) trials [2, 3], the GLP-1RAs rapidly and greatly decreased HbA 1c levels compared to placebo, which may have partly contributed to the increased incidence of diabetic retinopathy complications observed in SUSTAIN-6 (HR: 1.76 [95% CI 1.11, 2.78])
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