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Due to loss of hemoglobin O 2 binding, symptoms are largely related to O 2 deficiency

These undesirable consequences are influenced by the type and dose of xenobiotic and show considerable species differences in susceptibility and severity that need to be understood for assessing the potential effects on human health from similar exposures to specific xenobiotics

This celebrated success in extending human lifespan, however, has unveiled a significant paradox: the years gained are often burdened by illness