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Metformin in amnestic mild cognitive impairment: results of a pilot randomized placebo controlled clinical trial

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When testosterone levels decline, several physiological changes occur: Increased Fat Accumulation: Low testosterone is linked to higher body fat percentages, especially in the abdominal region

Metformin is the first line of treatment in newly discovered T2D patients and was first demonstrated to influence gut microbiota composition in diet induced obese mouse models, where it resulted in enrichment of Akkermansia muciniphila (39, 40), a gut commensal showing beneficial effects on metabolism (41)