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In clinical trials, tirzepatide demonstrated reductions in hemoglobin A1c of up to 2.5% and weight loss of approximately 15-21% of body weight at higher doses after 72 weeks of treatment, with results varying by dose and patient population

[DOI] [PubMed] [Google Scholar] 64.Diamond LE, Earle DC, Rosen RC, Willett MS, Molinoff PB

This reaction simultaneously depletes two critically important metabolic cofactors: SAM (the universal methyl donor for hundreds of epigenetic and biosynthetic reactions) and nicotinamide (the precursor for NAD+ biosynthesis via the salvage pathway)

The TRIUMPH-1 trial showed 24% body weight reduction at 12mg over 48 weeks a number that put the entire GLP-1 space on notice