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doi:10.1016/j.jaad.2014.10.032 28Feldmeyer L, Heidemeyer K, Yawalkar N

The Pyruvate dehydrogenase E1 component subunit beta, or pyruvate dehydrogenase (lipoamide) beta mitochondrial, synonym, PDE1-B, has gene located on chromosome 3 having length of 6198 bp [10-12]

Interestingly, in another study, although F1 generation offspring did not develop obesity, both male and female F3 generation were obese and presented differential DNA methylation in genes associated with this comorbidity [123]

analyzed 272 samples and found a significantly higher -AASA/creatinine ratio in this group of patients with a significant age dependency [24]