what is the max dose of retatrutide VisualAbstract: reduces body weight by 17.5% in patients with obesity Retatrutide Dosing Guide: 1-12 mg

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This efficacy/security gap suggests that orforglipron is unlikely to significantly erode the market share of subcutaneous formulations

Retatrutide showed a 7% discontinuation rate at the 12mg dose, while Mounjaro demonstrated a 6% discontinuation rate at 15mg

The GI symptomsnausea, vomiting, diarrhea, constipation, delayed gastric emptyingare present with both drugs and follow a similar dose-escalation pattern