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Kuehni et al., 2010)

This approach has proven efficacy, although often transient, in slowing disease progression and preserving residual beta cell function, particularly in recent-onset type 1 diabetes (sources for the efficacy of immunotherapy, e.g., from the Teplizumab trials)

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The fact that studies indicate that the majority of SIRT activators (or at least SIRT1-targeting activators) exert both direct activating effects and indirect effects via modulation of SIRT1 downstream pathways complicates the interpretation of results and, particularly, the mining of data specifically dependent on direct SIRT1 binding and activation