"Berberine may help reduce body weight modestly (about two to four pounds over several weeks) and lower HbA1c levels, but it lacks the robust, consistent results seen with GLP-1 medications like Ozempic, which can produce 15 to 20 percent body weight reductions in clinical trials." Diana Mesa, RDN, LDN, CDCES, founder of En La Mesa Nutrition, agrees, adding that "Berberine does have some similarities [to GLP-1 RA medications] in that it can trigger the pancreas to release insulin and helps make cells more sensitive to the effect of insulin, which is a characteristic similar to what Metformin [another prescription medication prescribed to treat type 2 diabetes and other off-label conditions] does." Still, she notes that it's unclear whether or not Berberine has any appetite-suppressing effects like Ozempic and similar medications
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Between-group comparison showed no significant difference for CTX, p = 0.08 ( p- value based on the log transformation), corresponding to relative changes of 9.96% and 2.02%, or for P1NP, p = 0.12 ( p- value based on the log transformation), corresponding to 1.23% and 1.15%, respectively
