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By contrast, amiloride (1 mM), a pharmacological inhibitor of macropinocytosis (34), clearly inhibited cellular internalization of FAM(2836) (Supplemental Figure 6, E and F)

developed microglia-targeted gene delivery systems-coated TREM2 plasmid to upregulate the TREM2 level in the brain, significantly regulated microglial polarization toward an anti-inflammatory phenotype, relieved neuroinflammation, enhanced A clearance, and improved cognitive performance in APP/PS1 mice

Chen L-H, Xu M, Cheng Z, Yang L-T (2024) Effects of nitrogen deficiency on the photosynthesis, chlorophyll a fluorescence, antioxidant system, and sulfur compounds in Oryza sativa