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A potential nonlinear positive correlation between dosage and therapeutic efficacy has also been suggested (Zhang et al., 2023)

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In particular, glutathione (GSH) depletion is a common feature of apoptotic cell death triggered by a wide variety of stimuli including activation of death receptors, stress, environmental agents, and cytotoxic drugs

The Activity of Catechol-O-Methyltransferase (COMT) Is Not Impaired by High Doses of Epigallocatechin-3-Gallate (EGCG) In Vivo