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GLP-1 exerts several key physiologic effects: Increases glucose-dependent insulin secretion Suppresses inappropriate glucagon release Delays gastric emptying Promotes satiety and reduces appetite Pharmacologic GLP-1 receptor agonists, including semaglutide, liraglutide, and tirzepatide, are engineered to resist DPP-4 degradation, allowing them to persist for hours to days

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While they all help you feel fuller longer and can lead to notable weight loss, your doctor prescribes a specific medication based on your personal health history, weight-management goals, and insurance constraints

3 They can also suffer from neuropsychiatric disturbances including mental retardation, behavioral disturbances, and epilepsy