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At the molecular level, the sulfur provided by MSM is strictly required for the proper synthesis and structural cross-linking of collagen, the primary structural protein that forms the scaffolding of all connective tissues, including cartilage, tendons, and ligaments

Arneimittelforschung 1977;27:598-605

In the UKPDS cohort, the development of eGFR 300 mg/g) as the main renal outcome and the other trials addressing also eGFR-related endpoints, RRT and renal death (Table 1) [11]