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Saroglitazar, a dual PPAR / agonist currently used in India for treatment of diabetic dyslipidemia has shown promising effects in experimental models of NASH [64] and seems also to be effective in humans, reducing serum aminotransferase levels and liver size assessed by ultrasound in NASH patients after a 24-week course [65]

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Moreover, melatonin may impact amyloid clearance via its impact on insulin-degrading enzyme (IDE), a protease pivotal for catalyzing extracellular and intracellular A degradation [63]