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Stillbirth rates are also slightly elevated at 0.6-1.0% compared to 0.4-0.6% in women without these conditions

Additionally, metformin may stimulate ovulation in those with PCOS or who are premenopausal, which may increase the risk of unintended pregnancy

The activity of GLP-3 has been evaluated in several randomized phase 2 clinical trials, demonstrating significant weight reduction

These medicines had significant effects on gastrointestinal emptying and postprandial glucose regulation, but these effects were restricted to meals consumed quickly after administration (Nauck and Meier 2019)