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For patients with atrial fibrillation and obesity, this work opens the door to a new treatment paradigm, Dr

Its protective effects are closely related to the inhibition of ferroptosis: Irisin can reverse the oxidative stress imbalance caused by sepsis, lower ROS and Fe 2+ levels in the lung, and downregulate the expression of ferroptosis-related markers (ACSL4, Ptgs2, and Hspa5) and proteins (ACSL4, COX-2, and p-AMPK), thereby exerting lung-protective effects (Zhang F

Randomized clinical trials were given particular consideration, although the evidence was not restricted to these studies, many of which are summarized in Appendix X

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