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This approach reframes GLP-1 therapy as one component of comprehensive metabolic and hepatic risk management rather than a surrogate for liver protection
Nat Metab 8 , 12501252 (2026)
Estrogen decline reshapes appetite signaling, shifts fat storage toward the middle, and changes how side effects feel, and it does all of this unevenly, sometimes month to month
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Appetite suppression and early satiety induced by GLP-1 receptor agonists can lead to reduced caloric and protein intake, increasing the risk of micronutrient deficiencies (notably vitamin D, B12, calcium, iron, magnesium, and zinc) and sarcopenia, especially during rapid or substantial weight loss
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