doi: 10.1016/j.euroneuro.2018.12.015 53
Metabolites in HIV-associated neurocognitive disorders (HAND) were similar to those of age-associated cognitive decline in the absence of HIV with elevated neurotransmitters (glutamate, N-acetylaspartate), markers of glial activation (myo-inositol), and ketone bodies (beta-hydroxybutyric acid, 1,2-propanediol) 55
Although several studies have demonstrated the efficacy of RSL3 in various animal models (32), non-specific effects of RSL3 cannot be excluded given its poor bioavailability in vivo ( To date, the majority of studies regarding drug-tolerant persister cells have focused on persister cells from immortalized cell lines, demonstrating that they occur as a small subset of the total tumor population (33)
[DOI] [PubMed] [Google Scholar] 220.Giger U, Sticher B, Naef R, Burger R, Lutz H