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doi: 10.1016/j.celrep.2021.108996 33 BongfenSENtsamaPMOffnerSSmithTFelgerITannerMet al

e-g , Muscle bulk RNA-Seq data presented as a heatmap focusing on: upregulated genes involved in oxidative stress, cellular metabolic process, branched chain amino acid metabolism, NAD, and pantetheinase (e), downregulated genes in extracellular organization and animal organ development (f), and genes in the ISR that appear minimally affected (g) in KO compared to Het mice at Day 2 on No Cys diet (See also Supplementary Table 3)

Analysis of the data indicates that short-term treatment with RM-493 increased resting energy expenditure significantly (by 6.4% vs placebo), thus suggesting RM-493 may be clinically effective for treating obesity

Another randomized controlled trial showed similar benefits