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Phase variation of HpuAB and HmbR, two distinct haemoglobin receptors of Neisseria meningitidis DNM2

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Membranes were blocked with 5% skimmed milk in Tris-buffered saline containing 0.1% Tween 20 for 1 hour at room temperature and incubated with primary antibodies overnight at 4 C

Its primary mechanism of action involves increasing the expression of Brain-Derived Neurotrophic Factor (BDNF) in the cerebral cortex and hippocampus, promoting neuroplasticity, the formation of new synapses, and neuronal survival