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It also modulates inflammatory signaling, reducing excessive inflammation that can impair healing while maintaining the beneficial inflammatory signals needed to recruit stem cells and initiate repair

FIGURE 1 3.2 Daphnetin attenuated oxidative stress of diabetes cognitive dysfunction rats As shown in Figure 2, STZ-treated caused oxidative stress in rat brain, which increased the MDA content and GSSH content, and reduced the levels of SOD, CAT, GSH, Gpx and TAC, while daphnetin-treated inhibited these changes in oxidative stress-related medicators, which indicated that daphnetin could mitigate oxidative stress of diabetes cognitive dysfunction rats

After 15 min, all rats received an injection of fentanyl (75 g/kg, IV)