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When the valves fail, this causes a further increase in pressure and blood pooling in the legs which becomes a vicious cycle of increased pressure and further venous distention

49 However, TACE is associated with a high rate of side effects, 10 among which pain is the most common clinical symptom and is frequently associated with prolonged hospitalization and poor compliance for repeat TACE

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The Bcl-2/Bax ratio increased and cleaved caspase-3 levels dropped, indicating reduced apoptosis (Pyo et al., 2007)