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[14] Skeletally, the hormone increases osteoprotegerin and decreases RANKL, dampening osteoclast differentiation and prolonging osteoblast survival, translating to measurable gains in lumbar-spine mineral density within twelve months of therapy
Microdosing can help minimize the risk of those effects by starting at a very low level and increasing the dose gradually
There is also biochemical rationale for a link between fasting and hemoglobin levels [8], and an observational study of religious intermittent fasting demonstrated an increase in hemoglobin [9]
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