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In a 12-week, randomized trial of the gut-targeted berberine-ursodeoxycholate co-crystal (HTD1801) involving 113 adults with type 2 diabetes, the higher dose (1 g twice daily) lowered HbA1c by 0.5 percentage points relative to placebo and produced parallel reductions in fasting glucose

Optimize your sleep position Sleeping on your left side reduces reflux episodes compared to sleeping on your right side or your back

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Persistent vomiting that doesn't improve with dose adjustment or dietary changes warrants a conversation with the prescribing doctor about whether to continue at the current dose