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Mechanism of Action Ipamorelin functions by selectively binding to and activating the growth hormone secretagogue receptor (GHS-R1a), which is expressed in the pituitary gland and various peripheral tissues

No topical agent has demonstrated sustained cellulite reduction in rigorous clinical trials

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Coordinated pathological changes include fibrosis, stromal stiffening, and myofibroblast expansion in both compartments, which compromise joint biomechanics and serve as sources of persistent nociceptive signaling (Tang et al., 2024