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Thus, oxidative stress, as with inflammation, is regarded to be a key aggravating factor for the initiation and progression of AKI and CKD, including diabetic nephropathy, hypertension-associated kidney disease and toxic-induced nephropathy [18,20,24]

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Then pENTR/U6-shRNA plasmids were recombined with the Gateway based pAd-BLOCK-iT DEST vector (Thermofisher) to generate pAd shRNA vector

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