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Enrique Caballero, an endocrinologist at Harvard-affiliated Brigham and Women's Hospital

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In contrast, the results of qRT-PCR revealed that the expression levels of key genes ( BECN1 , ATG3 , ATG4D , ATG5 , ATG12 , and SQSTM1 ) of the autophagy signal transduction pathway in HuOCSCs overexpressing ATF4 and treated with anisomycin were significantly higher than those in the control group (Figure 6B)

However, MM is still incurable for the majority of patients who become refractory to treatment and ultimately relapse, thus further development of new therapeutic agents is warranted, such as specific inhibitors targeting activated oncogenes