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The current standard operating procedure by the European Center for the Validation of Alternative Methods (ECVAM) recommends the use of MTT reduction as parameter to make prediction on the skin irritancy of substances using EpiSkin TM test method, while IL-1 endpoint is regarded as a useful adjunct to MTT assay 48

Another study using the same mouse tumor model found that, in mice given a high dose of EGCG, there was a greater degree of tumor reduction than in mice given cisplatin

The GHK-Cu complex then helps coordinate the healing response

However, no deleterious side effects have been reported in the literature thus far