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It downregulates inflammatory mediators such as IL-6, indirectly modulating hepc activity and restoring iron homeostasis (87, 88)

Meta-analysis was performed using a random-effects model

Graphical Abstract Keywords Liver, Cardiovascular system, Metabolite, Extracellular vesicle, Hepatokine Introduction Although remarkable advances have been made in clinical and basic research fields, cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality, and impose a significant global health care burden

That is double your starting dose, which may trigger significant gastrointestinal side effects including nausea, vomiting, and diarrhea