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In addition, we observe that rotation of TM6 in the active-state structure breaks the interaction between S247 6.44 and NPxxY motif residue N296 7.49 , allowing local rearrangement of NPxxY motif residues P297 7.50 and Y300 7.53

3 Substrates for GSH synthesis are provided either by transport of amino acids into the cells or by transpeptidase activity at the cell surface, which is responsible for salvaging amino acids from circulating GSH for reuse in the intracellular resynthesis of GSH