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However, there were no significant changes in FEV 1 or FEV 1 /FVC ratio [80]

The unexpectedly profound weight loss observed in diabetes trials drove development of a higher-dose formulation Wegovy (up to 2.4 mg weekly) which received FDA approval in 2021 and EMA approval in 2023 specifically for chronic weight management in adults with obesity or overweight with at least one weight-related comorbidity

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