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Side Effects and Tolerability All three products share the gastrointestinal side effect profile associated with GLP-1 receptor agonism: nausea, vomiting, diarrhoea, constipation, and abdominal discomfort are the most commonly reported adverse events, typically emerging during dose escalation and improving over time
On Wegovy (semaglutide 2.4 mg, approved for chronic weight management): The FDA-approved prescribing information for Wegovy discloses that in the SELECT cardiovascular outcomes trial - a large study conducted in adults with established cardiovascular disease - hip and pelvis fractures were reported more often in female patients on Wegovy than in those on placebo: 1% (24/2,448) versus 0.2% (5/2,424)
So the shrinking of fat cells can change our hunger signaling in a compound effect
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