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Cold-turkey discontinuation may set up regain because four forces converge: appetite returns as the drug washes out, lean mass lost during the deficit is already gone, retatrutides glucagon-arm metabolic lift fades fast, and hunger-hormone defenses persist for about 12 months after major weight loss

Faster, cleaner recovery lets a non tested athlete train more consistently, and consistency is what actually drives progress over months

Moreover, the duration of the treatment being carried out, that is a number of sessions one takes and the aftercare also impacts the efficacy of the treatment

doi: 10.1016/j.cell.2014.10.039