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Ephelides, commonly known as freckles, are characterized by hyperpigmented brown macules found on sun-exposed areas during childhood

[7] Causes of upper gastrointestinal bleeding that may result in melena include malignant tumors affecting the esophagus, stomach or small intestine, hemorrhagic blood diseases, such as thrombocytopenia and hemophilia, gastritis, stomach cancer, esophageal varices, Meckel's diverticulum and Mallory-Weiss syndrome

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The exact number depends on your starting skin tone, desired results, dosage used, and individual response to treatment