Several studies have found that how long B12 remains in the system can depend on underlying factors such as tendencies towards developing certain diseases and lifestyle choices
An important example is recent data on immune checkpoint inhibitors, demonstrating that there is a significant difference in immune responses in men and women, with the higher possibility for males to benefit from cancer immunotherapies (172)
It can be assumed that oxidative damages cause alterations in the structure of lens proteins, while antioxidant metalloenzymes relied by zinc, such as SOD, protect the lens (27)
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