Notably, GSH depletion and/or GPX4 downregulation have also been linked to pathological oxidative stress in vivo, such as ischemia/reperfusion cardiac injury and doxorubicin induced cardiomyopathy 41, 42
In this context, the rise in glucose may indicate reduced cellular utilization, potentially secondary to insulin resistance or mitochondrial inefficiency
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Demand and insurance coverage will likely continue to increase as GLP-1s are used to treat a broader set of issues like sleep apnea, cardiovascular disease, kidney disease, Alzheimers and even Parkinsons