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These challenges have catalyzed the search for innovative strategies for early detection, prognosis, and precision treatment that can augment the current standard of care defined by international guidelines such as KDIGO (Kidney Disease: Improving Global Outcomes KDIGO CKD Work Group, 2024)

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albicans , which triggers the activation of TANK-binding kinase 1 (TBK1)a serine/threonine kinase central to innate immune signaling cascades that regulates the production of type I interferons (IFN-I) and proinflammatory cytokines (Perry et al., 2005)