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AOD-9604 has an additional tyrosine residue added at the N-terminus, which improves stability and may slightly enhance lipolytic activity

Patients who do not see measurable response by month 3 should reassess with their provider rather than continuing indefinitely

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Preclinical investigations have indicated that SAMHD1, a myeloidspecific restriction factor, inhibits HIV replication through the degradation of intracellular deoxyribonucleoside triphosphates (dNTPs), thus maintaining dNTP concentrations below the threshold necessary for HIV1 reverse transcription